On complex dynamics in a Purkinje and a ventricular cardiac cell model

Cardiac muscle cells can exhibit complex patterns including irregular behaviour such as chaos or (chaotic) early afterdepolarisations (EADs), which lead to sudden cardiac death. Suitable mathematical models and their analysis help predict the occurrence of phenomena decode mechanisms. The focus this paper is investigation dynamics described by systems ordinary differential equations. This generically performed studying a Purkinje cell model modified ventricular model. We find chaotic with respect leak current in model, EADs reduced fast potassium an enhanced calcium -- features that have been experimentally observed are known exist some models, but new under present consideration. also investigate related monodomain both study synchronisation on macro-scale connection discovered features. show qualitatively same what has observed. However, for certain parameter settings occur within non-physiological range.